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In PCOS granulosa cells, despite the absence of evidence directly substantiating Cer-mediated pro-senescence effects, this bioactive sphingolipid has been demonstrated to elicit oxidative stress [12], mitochondrial dysfunction [22], and DNA damage [23], all of which are critical drivers of cellular senescence [24]

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Glutathione depletion by hyperphagia-induced obesity

Topical Application: In the cosmetic industry, glutathione is used in creams and serums