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Aberrations in temporal rhythms can both directly and indirectly enhance cardiovascular and cerebrovascular disease (Morris et al., 2012) increasing obesity (Shi et al., 2013), inducing insulin resistance and metabolic disorders (Marcheva et al., 2013), promoting premature aging (Savvidis and Koutsilieris, 2012

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At the midpoint between the two pKa values, the following measure of net negative and hint of net positive particles balance, so that the typical net charge of all structures present is zero

J Clin Pharm Ther 2003;28:289-94