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Vial fell or was shaken accidentally If a reconstituted vial was shaken vigorously (dropped, thrown in a bag, held by a toddler), some peptide degradation may have occurred

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Once the intracellular pool of GSH is exhausted, NAPQI covalently combines with cellular proteins, which results in mitochondrial dysfunction and oxidative stress 5

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3) and the rescue of the growth phenotype (Supplementary figure 3), it can assist in oxidative folding of PhoA in the absence of DsbA