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These endogenous gut hormones act on the central nervous system either via the circulation through areas deficient in the bloodbrain barrier, such as the median eminence of the hypothalamus and the area postrema [5] or via receptors of vagal afferents, together with stretch receptors and nutrient chemoreceptors [6]

Curr Drug Targets 7(3):371383 Oberlies NH, Kroll DJ (2004) Camptothecin and taxol: historic achievements in natural products research

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