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The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized: Anaphylaxis and death Cardiovascular: Pulmonary edema and congestive cardiac/heart failure during early treatment

Signs of infection include increasing pain, warmth, spreading redness, or purulent discharge, and require prompt medical assessment

Mistakes in the formation of DNA and RNA can lead to severe diseases (5-7)

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice.[J]