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Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

Circadian rhythm, stress reduction, and pacing have to be actively managed

10.1038/s41598-021-87367-9 30 DwivediD.MeghaK.MishraR.MandalP

Proceedings of the National Academy of Sciences of the United States of America 108: 95489553

Disadvantages involve benefit decline during off periods requiring acceptance of fluctuation, complexity planning and tracking cycles, uncertainty about optimal timing and duration for individual responses, and potential for forgetting to restart after extended breaks

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