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Consistent with the loss-of-function effects of genetic variations in human CAMKK2 , mice lacking Camkk2 display behavioural traits similar to those frequently observed in bipolar disorder [33]

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Retatrutide is an investigational triple agonist peptide being developed by Eli Lilly, designed to simultaneously target GLP-1, GIP, and glucagon receptors a mechanism that distinguishes it from currently approved agents such as semaglutide and tirzepatide

& Gunn, R