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Yet, large goiters can obstruct the trachea and esophagus and damage the recurrent laryngeal nerves

Effects of alogliptin in chronic kidney disease patients with type 2 diabetes

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A study by Raygan et al

HO is further compounded by the associated comorbidities that include endocrine dysfunction with multiple pituitary hormone deficiencies, sleep disturbance, visual dysfunction, and neurological sequalae due to the intimate colocation of the hypothalamus with other structures such as the pituitary gland, optic chiasm, and cavernous sinus [54]

This log becomes critical if you need to assess whether a vial is still usable after an unplanned exposure event