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More importantly, the mechanical trauma of the needle can trigger a post-inflammatory melanin rebound that darkens the lip beyond its pre-procedure state, particularly in phototypes IV to VI

Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on June 6th, 2025

Last medically reviewed: 2026-04-27 by GLP3 Planner editorial

Adding compounds like glycine with tirzepatide or glycine and B12 combinations may provide additional support for connective tissue and muscle metabolism

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