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Even more frequently, non-specific resistance mechanisms, involving modification of cell envelope charge, composition or rigidity as well as increased expression of drug resistance transporters can contribute to resistance

Texture and Application

The Wegovy label summarizes this "increase every 4 weeks" approach

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Obesity (Silver Spring) 2020;28:10501061

In addition, our data unambiguously documented that the effects of this and other multi-functional analogs on body weight and food intake are not merely due to food aversion or malaise linked to gastrointestinal distress, regarded as one of the main side-effects of GLP1-based therapy in humans 49