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The beneficial effects of IGF-1 treatment in AKI may be due to the following: (1) its stimulatory effect on GFR via increased renal blood flow ( vide supra ), which prevents the obstruction of tubules by cellular debris and thereby limiting the extent of kidney injury

Yao Y, Cai X, Fei W, Ye Y, Zhao M, Zheng C

Every cell with a steroid receptor responds, whether you intended it to or not

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suggesting that, at high concentrations, IGF-1 has effects not simply mediated by suppressing the effect of GH on hepatic insulin sensitivity [129, 209]

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