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doi: 10.1016/s0165-6147(00)01664-3

If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every 3 to 4 days for another 2 to 3 weeks

Earlier shorter trials reported small statistically significant differences but the effect sizes were modest

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Clinical trials using oral glucose tolerance testing demonstrated that AOD-9604 has no negative impact on carbohydrate metabolism or insulin sensitivity