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Kornienko IV, Aramova OY, Tishchenko AA, Rudoy DV, Chikindas ML

Among these, Claudin-5, Occludin, and zonula occludens-1 (ZO-1) are central to maintaining the structural integrity and function of tight junctions (61).Claudin-5, a principal protein in inter-endothelial tight junctions, determines BBB selective permeabilitys (62)

Among these molecules, activation of CREB and inhibition of GSK-3 and FoxO1/O3 are likely to participate in the neuroprotective activities of insulin, IGF-1, and GLP-1 toward DRG neurons (Leinninger et al., 2004