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Hippocampal slices were treated with various inhibitors in order to observe changes in CA1 fEPSPs and EPSCs

For those with IR, metformin can be prioritized as foundational metabolic management

This is a relatively new weight loss medication

Research on the safety and efficacy of such combinations is a critical area of study ( in silico molecular docking results indicated that sitagliptin may exhibit putative binding affinities with the DPP4/CTNNB1/MET signatures, surpassing those of standard inhibitors for these genes

This suggests GLP-1 receptor agonists should be further studied for their potential effectiveness for treatment of binge-eating disorder