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While increased heart rate is generally a counter-regulatory response that could blunt BP reduction, the overall blood pressure effect of GLP-1 RAs remains a net decrease, as other mechanisms such as vasodilation, natriuresis, and weight loss dominate

As a validation step, the method successfully identified well-established side effects like nausea, confirming it picks up real signals

Addition of the nucleophile can take place via an attack on the carbon (addition 14) or on the carbon at (addition 16)

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This makes the process faster and easier

[PubMed: 20647200] 47