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Both medications are FDA-approved, undergo rigorous pharmacovigilance, and show serious adverse event rates below 2%

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Both remain preclinical compounds, and findings have not been confirmed in human trials

Most adverse events were found to be mild-to-moderate GI symptoms, including nausea and diarrhea, with no reported severe hypoglycemia or cardiovascular complications [10]

Moreover, numerous studies have reported that inhibiting NLRP3 activation and inflammatory cytokine secretion decreases to occurrence of epileptic seizures and ameliorates cognitive dysfunction (17,18)