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GI tolerability exceeding current incretin therapies, particularly vomiting, which is a common reason for therapy discontinuance

Goldberg SB, Tucker RP, Greene PA, et al

Indeed, several studies have proposed that DAM contribute to the clearance of neuronal debris, including synaptic structure, a function inferred from their transcriptional profile as described by Keren-Shaul et al

However, a series of downstream inflammatory pathways activated after ferroptosis cannot be ignored, and these pathways further promote angiogenesis and focal fibrosis (Fig

For example, combinations of redox-active drugs and metal ions, such as copper or silver, can promote thiol oxidation

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for diabetes and obesity, exhibit pleiotropic effectsincluding anti-inflammatory, antioxidant, and neuroprotective propertiesthat position them as transformative candidates for ocular therapeutics