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It should be the very last resort

Biophys ., 2012, vol

Commonly taken as a supplement in the fitness and bodybuilding world, creatine has gained popularity for its ability to support short bursts of high-intensity exercise, improve recovery, and increase lean muscle mass

doi: 10.1038/S41556-023-01150-8 216 ZhuHWangGNguyen-NgocKVKimDMillerMGossGet al

Excluding the few exceptions where methionine may act as a redox sensor (e } : CS1 maint: multiple names: authors list (link) "Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age"

This blend is supplied as a lyophilised powder to support stability during storage and handling