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Overall, its considered safe to use GLP-1 RAs for the long term

This educational review aims to examine semaglutide and its recommended dosages for a number of uses

10.1371/journal.pone.0027260 12 ChenH.MorrisM

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It is also chosen by those who are unable to use the FDA-approved versions due to specific health reasons or other factors like allergic to any component of the drug (for example, dye)) or inability to take the drug in solid oral form such as tablets or capsule (which often occurs in children and elders), or if the physicians believe that the drug is not medically appropriate to treat the patient

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