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Early management with hydration, diet adjustments, or dose pacing usually resolves symptoms without interrupting progress

If youre pregnant, planning to become pregnant, or currently breastfeeding, consult your provider to explore safer alternatives

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The good news is that insulin doesn't need to be refrigerated all the time

Most patients experience no adverse effects, and when present, theyre typically mild and transient including temporary digestive changes as the gut adjusts, minor nausea (usually resolving within days), or altered bowel patterns during initial therapy

10.1161/CIRCULATIONAHA.122.059595 112 MascoloA.di MauroG.CappettaD.De AngelisA.TorellaD.UrbanekK.et al (2022b)