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doi: 10.1210/jc.2003-030049 155 NauckMANiedereichholzUEttlerRHolstJJOrskovCRitzelRet al

These results are from short-duration rodent studies and do not indicate that comparable outcomes occur in humans

Patients discontinued semaglutide at a higher rate compared to placebo, mostly due to a higher rate of gastrointestinal adverse events (6.8% vs 1.6% of treatment and placebo patients, respectfully)

Start Low, Go Slow: This is the golden rule

Below is a tiny sample of Reddit and Facebook threads that capture common themes from patients and clinicians navigating long term GLP-1 use: Closing Thoughts Long term use and discontinuing GLP-1s is unlikely to follow a single, uniform pathway

These injections can help accelerate the breakdown of fats and carbs, supporting a healthier metabolic rate