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In early phase 2a trials, it effectively improved glycemic control, increased post-meal insulin levels, and facilitated weight loss in participants with obesity and patients with T2DM [83]

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In addition to the indirect consequences of long-term oral antibiotic consumption on intestinal barrier health, particularly through reducing the numbers of SCFA-producing species, these therapeutics have also been reported to directly impair the gut barrier by reducing the expression of TJ proteins and negatively impacting their morphology

doi:10.1111/j.1365-2982.2010.01468.x