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Methionine is needed for DNA synthesis and methylation reactions

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B12 books I found useful "What You Need to Know About Pernicious Anaemia and B12 Deficiency" by Martyn Hooper Martyn Hooper is the chair of PAS (Pernicious Anaemia Society)

Its mechanism NNMT inhibition leading to AMPK activation directly improves insulin sensitivity, as demonstrated in the 2021 Nature Metabolism study where treated mice showed reduced hepatic steatosis and improved glucose tolerance