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The clinical data underscores both the potential and the challenge: while mechanistic studies are convincing and smaller trials encouraging, large randomized trials sometimes fail to meet endpoints, reminding us of patient complexity and the need to target the right patients

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Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, et al

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Plasma acyl-carnitine profiles of subjects Plasma acyl-carnitine levels of each group are illustrated in Fig