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The meta-analysis by Wang and colleagues 137 included an unpublished trial (NCT00845507 145 ) that was not part of the more recent meta-analysis by Khaity and colleagues 134

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Results are based on factors like baseline weight, adherence to the medication regimen, lifestyle changes, and individual metabolic factors

doi:10.1161/hyp.74.suppl_1.051 95

b The level of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) or specific criteria by the individual meta-analysis

Conclusion Because of its feed-forward effects and oral bioavailability, GHRP2 hormone replacement may provide a more holistic approach to GH-directed therapy