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The term "a constant pH-value", as used herein is intended to mean that the pH-value may be constant, such as in the presence of a buffer or may vary typically within 3 pH units, if no buffer is present

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TMAO reduces bile acid pools, inhibiting FXR activity, disrupting bile acid-FXR signaling, and upregulating pathways worsening hepatic steatosis, as confirmed in HFD-fed C57BL/6J mice and human samples (154)

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