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In July 2023, the EMA initiated an inquiry into safety concerns after receiving approximately 150 spontaneous reports indicating potential links between drugs and suicide ideation or self-harm [72]

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Therefore, any relationship between GLP-1 therapy and muscle cramps is more likely to be indirect, mediated through secondary metabolic, nutritional, or fluid balance alterations rather than through direct receptor-mediated effects on muscle tissue

"Glutathione-mediated biotransformation in the liver modulates nanoparticle transport." Nature Communications

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