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Evidence for Kidney Benefits Clinical trials show consistent kidney benefits: FLOW trial (semaglutide): This dedicated kidney outcome trial showed semaglutide reduced the risk of major kidney outcomes (kidney failure, significant decline in kidney function, or kidney-related death) by 24% in diabetic patients with chronic kidney disease

Our hypothesis is further supported by the finding that for the sub-group of patients defined a priori as having residual schizophrenia, the effect size was larger, and indeed was largely responsible for the difference in scores between patients and controls