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Briefly, after the mice were anaesthetized with 60 mg/kg sodium pentobarbital, a stereotactic device was used to implant electrodes into the cerebral cortex on both sides of the bregma

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Table 18: Percent Change from Baseline in BMI after 52 Weeks of IMCIVREE Treatment in Patients Aged 2 to Less Than 6 Years with Obesity due to POMC Deficiency, LEPR Deficiency, or BBS (Trial 5) Supportive of IMCIVREEs effect on weight loss, general numeric improvements in waist circumference were observed

doi: 10.1210/jc.2008-0751 103 HaqqLMcFarlaneJDiebergGSmartN