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In summary, SCLA1, SCLA2 and SCLA3 induced ferroptosis, which correlated with the identification of GPX4 as a target for these SCLAs in pulldown experiments and senescence selectivity of engagement with these SCLAs

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Insulin resistance (IR) is not the leading cause of obesity, although obesity really does worsen the insulin resistance of polycystic ovarian syndrome (PCOS) and hyperandrogenemia

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11 Bone marrow suppression is common and potentially affects all cell lines, with megaloblastic anemia being most common