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Despite growing interest in mushroom-derived therapeutics, existing clinical studies remain limited by several important constraints

doi: 10.1007/978-3-031-21054-9_16 120 HowrenMBLamkinDMSulsJ

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Additionally, therapeutic approaches targeting microbial metabolites, such as SCFA supplementation or modulation of tryptophan metabolism, are under investigation and may offer novel preventive or therapeutic options (Bourgonje et al., 2024

IGF-1 is also responsible in part for the regulation of lipogenesis, which is thought to occur through IGF-1s effects on 5-Reductase and the enzymatic process responsible for converting testosterone into DHT, which stimulates sebocyte proliferation

Another REALLY important thing to consider is how the weight loss occurs in these individuals