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In a familial form of amyotropic lateral sclerosis (ALS), a dominant gain-of-function mutation of the gene encoding superoxide dismutase (SOD) leads to production of reactive astrocytes of molecules that are toxic to motor neurons

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J Biol Chem (2008) 283:1697184

At the level of the whole liver, changes in metabolites induced by regeneration (regenerating livers compared with the corresponding resected livers) were quite similar between SLC25A51-overexpressing livers and eGFP controls (Fig