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Because semaglutide slows gastric emptying and acts on appetite pathways in the brain, many users feel less hungry and become satisfied with smaller meals

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349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy