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Furthermore, CHAC1 negatively regulates the NOTCH1 receptor, a key player in determining cell fate, particularly in neuronal stem cells, affecting their development and differentiation ( 2.1 CHAC1 upregulation under arsenite stress and amino acid depletion As a stress-responsive protein, CHAC1 is critically involved in the cellular stress response

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The bacterial strains used in this study were selected to be representative of each phylum present in the gut microbiome ( 42, 43 )

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