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Table 1 Characteristics of available GLP-1 receptor agonists

Seasonal storage adjustments Your storage needs shift with the seasons

Of medical importance, the discovery of the DPP-4 protease resistant exendin-4 from venom of Heloderma suspectum paved the way for the successful development of GLP-1 analogues as important treatments for insulin resistant type 2 diabetics

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General guidelines and dosing for patients with T2D: Initiate pramlintide at the 60 mcg dose taken immediately prior to major meals Titrate pramlintide to 120 mcg dose after 3 or more days with no clinically significant nausea Optimize insulin to achieve glycemic targets once the maintenance dose of pramlintide is reached and blood glucose concentrations are stable Practical Tips for Patients On Pramlintide Start With a Low Dose and Titrate Slowly Pramlintide can cause nausea, anorexia and vomiting, especially in T1D where a more gradual titration is required

Nausea, constipation, or diarrhea most common during dose escalation and typically temporary