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In the pancreas, Saxenda enhances glucose-dependent insulin secretion whilst suppressing inappropriate glucagon release
Semaglutide and the other candidates identified are not being prescribed for TBM, and physicians should not interpret this as a signal to use them off-label in TBM patients outside of a formal clinical trial setting
Gastaldelli A, Cusi K, Fernndez Land L, Bray R, Brouwers B, Rodrguez (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial
A RCT ( n = 23, liraglutide between 6 weeks and 6 months post-op) randomised participants to 3.0 mg liraglutide or placebo after laparoscopic sleeve gastrectomy
Tirzepatide-Based Options Mounjaro Approved for type 2 diabetes, also prescribed off-label for weight loss
