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Available online: [DOI] [PubMed] [Google Scholar] 25.Silberstein S., Neto W., Schmitt J., Jacobs D

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147 Overexpression of miR-144-3p could downregulate the GSH/GSSG ratio, increase the levels of ROS, Fe 2+ , and ACSL4, promote ferroptosis and thus reduce the metastasis of osteosarcoma cells, while high expression of ZIB1 plays the opposite role, 147 indicating that miR-144-3p and its downstream ZIB1 are involved in the development and metastasis of osteosarcoma mainly by interfering with iron metabolism and redox homeostasis

Possible Side Effects: Nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, belching, hypoglycemia, flatulence, gastroenteritis, and gastroesophageal reflux disease

Historically, AOMs have been characterized by modest weight loss and side effects which are compliance-limiting, and in some cases life-threatening