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We have learned that many of the GLP-1 benefits in humans are also weight-loss independent, which is fascinating. Even albiglutide (Tanzeum, GlaxoSmithKline), which was taken off the market because it wasnt as good as other GLP-1s at reducing glucose and weight, reduced risk for major adverse cardiovascular events (MACE) by 22% compared with placebo despite no difference between the groups in weight loss, he said

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NCT04255433) is expected to provide definitive answers on the impact of tirzepatide on cardiovascular disease compared with dulaglutide, a long-acting GLP-1 RA that has been shown to be cardioprotective in individuals with type 2 diabetes at increased cardiovascular risk [31]

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