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10.1038/s41598-018-26704-x Sci

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In glioma, epidermal growth factor receptor (EGFR) activation increases 6PGD phosphorylation and activation to promote DNA synthesis and resistance to radiation (73)

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If its painful, spreading, interfering with sleep, or getting worse after a dose increase, its worth asking whether staying at your current dose, lowering the dose, or pausing treatment makes sense