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Joint pain while taking tirzepatide may stem from several factors: Rapid Weight Loss Effects : When you lose significant weight quickly (as many do on GLP-1 medications), your body undergoes biomechanical changes that can temporarily stress your joints

Protein and calorie intake

In the landmark SURMOUNT-1 trial, participants on the 15 mg dose achieved average weight loss of 22.5% of body weight over 72 weeks

This formulation improves the drug's bioavailability by enhancing gastric mucosal absorption

For the most current information, our retatrutide availability tracker is updated regularly as new developments emerge

Retatrutide has not received MHRA or EMA marketing authorisation and must only be used within a registered clinical trial or an approved early-access programme under direct medical supervision