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This response was characterized by increased production of CD3+, CD4+, and CD8 + T cells, as well as co-stimulatory CD80 and integrins [79, 154]

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receiving honoraria for lectures from Nippon Boehringer Ingelheim Co., Ltd., Sumitomo Pharma Co., Ltd., Teijin Pharma Ltd., MSD Corporation, Eli Lilly Japan K.K., Mitsubishi Tanabe Pharma Corporation, Taisho Pharmaceutical Co., Ltd

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This compromise in BBB integrity allows for the entry of substances that would normally be excluded from the brain parenchyma