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Visceral adipose tissue releases free fatty acids directly into the portal circulation, increasing hepatic very-low-density lipoprotein (VLDL) production

The further synergistic combination approach with other gastrointestinal hormones and creation of dual GIP/GLP-1 receptor agonists, such as tirzepatide and GLP-1/GIP/glucagon receptor triagonist, retatrutide, has shown unprecedented pharmacologically achieved weight loss with further cardiometabolic benefits in both obesity and T2DM

The SURMOUNT trial program proved it with hard data, showing tirzepatide weight loss results that exceeded anything achieved by GLP-1-only medications

What Foods Increase GLP-1 Levels

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