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One-time exhaustion exercise (forced weight-bearing swimming until exhaustion) reduces LC3-I to LC3-II conversion, downregulates PNIK1, SIRT1, PGC-1, Mfn1, and Drp1 protein expression, and upregulate p62 protein expression in the hearts of obese mice induced by high-fat diet

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It is a minimally invasive procedure, which means it does not require major surgery