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Altering peptides at the amino-acid level While the strategies for optimisation of small molecules are well established, such as adjusting lipophilicity, installation of (bio)isosteres and using prodrugs, similar strategies for use in peptides are far less developed

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DG wrote the manuscript

At week 16 of the phase III, randomized, BRIDGE study, PASI 75 was reached by more than one third of patients enrolled (8), while in the large retrospective FUTURE study it was demonstrated a mean reduction of 79% in PASI from baseline (72)

O., Elviro, R., Wevers, R., and Guijarro, G

Low GSH is not just a consequence of insulin resistance it may also feed the cycle, worsening mitochondrial dysfunction and impairing insulin signaling