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The involved processes include improper handling of intracellular Ca 2 , ER stress, mitochondrial dysfunction, the accumulation of AGEs, and the buildup of the extracellular matrix (ECM)

He said the true effects of using such products might not be clear for years and could pose an increasing risk of cancer, including among younger people

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The most important diseases affecting the hosts' immune responsiveness, and thus allergic responsiveness, include infectious disease, neoplastic disease and immune deficiencies