compounded tirzepatide vs tirzepatide $125/mo (vs $1,069 Mounjaro) What is the latest update

Patients should be proactive in reporting any changes in their health status or concerns related to the medication switch

The SURMOUNT-1 trial (tirzepatide, published in NEJM 2022) demonstrated that participants with obesity or overweight without diabetes who received tirzepatide experienced weight reductions of 16.0% (5mg), 21.4% (10mg), and 22.5% (15mg) over 72 weeks

References: Drucker, D

Off-label prescribing: If the doctor is prescribing Zepbound for an indication other than its FDA-approved uses, insurers may be less likely to cover the costs

The findings of a Phase 3 clinical trial, conducted with 307 participants, showed the efficacy of the tablet, with significant variation between results from patients taking Wegovy compared to those on placebo

Such ideas have now been practically implemented in the field of drug discovery and multiple new strategies such as small molecule inhibitors (SMIs), proteolysis-targeting chimeras (PROTACs) and molecular glue degraders targeting the co-activators are being considered through extensive research (Fig