In the Phase 3 TRIUMPH-4 trial, 33% of participants on the 12 mg dose reported diarrhea compared to 13.4% on placebo (Wang et al., Syst Rev Meta-Analysis, 2025)
For each calendar year, we calculated rates describing the overlap between semaglutide or tirzepatide prescriptions and PCOS diagnoses: Among female patients who received a semaglutide or tirzepatide prescription in a given year, we calculated the proportion who had a recorded PCOS diagnosis in or before that year
The article delves into the physiological causes of fatigue associated with GLP-1 treatments, including the impact on gastric motility and energy intake
Collagen and elastin decline with age, and rapid weight changes can outpace skin recovery
(Shanghai) 45 , 5160 (2013)
For people who are sensitive to nausea or have a history of gastrointestinal issues, this difference can be the deciding factor between the two peptides