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Serotonin stimulates the 5-HT 3 receptor to release acetylcholine in the nerve ends, which causes smooth muscle contraction and enhanced intestinal secretion ( 3 receptor antagonists which inhibit the 5-HT 3 receptor activation on the mucosal processes of the primary afferent neurons, and reduce activity of the secretory and motor reflex, by inhibiting the submucosal plexus and myenteric plexus respectively (Figure 2)

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In dermatology, these properties are particularly relevant for treating chronic inflammatory diseases such as psoriasis, hidradenitis suppurativa (HS), acanthosis nigricans (AN), and Hailey-Hailey disease (HHD)

The only thing I had to say is I should have started sooner