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The continuation group
Trough Levels (lowest concentration) occur just before your next dose and may result in increased hunger or reduced fullness
Other problems that might result from Prader-Willi syndrome include the following: Consequences of excessive consumption of food: An abnormally large stomach might be the result of the behavior known as binge eating, which involves ingesting massive quantities of food quickly
The decision depends on factors such as: Starting BMI Weight-loss history Type 2 diabetes or insulin resistance Surgical and anaesthetic risk Medication tolerance Patient preference Long-term treatment goals NICE also emphasises that bariatric surgery assessment should involve a multidisciplinary team with medical, nutritional, psychological and surgical expertise
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Common adverse effects , particularly during dose titration, include: Gastrointestinal symptoms: nausea (12-22% of patients), diarrhoea, vomiting, constipation, and abdominal discomfort Decreased appetite, which contributes to weight loss but may be troublesome for some patients Injection site reactions (usually mild) Fatigue (less common than gastrointestinal effects) Gastrointestinal adverse effects are typically most pronounced during the first 4-8 weeks and often improve with continued treatment
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