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Even more promising for weight loss, a 40-week study of 475 participants with diabetes published in 2022 in the Journal of the American Medical Association ( JAMA ) found that those on a 15 mg dose of tirzepatide lost an average of 19 pounds as compared to the placebo group who actually gained almost four pounds during the trial

We're completely shooting in the dark." Miras predicts a future where such information will be used to identify the most suitable weight loss drug for a particular patient, the likelihood that they will become resistant to it over time, and different combinations of drugs which could be used to keep their weight under control

In addition, a large number of clinical studies have shown that GLP-/GIP dual agonists can reduce LFC, VAT, and body weight, and have an improvement effect on both NAFLD and NASH [131,132]

This dual mechanism often produces more significant results

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Pharmacovigilance Risk Assessment Committee (PRAC): minutes of the meeting 7-10 January 2013